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Afatinib is an irreversible ErbB family of blockers that suppress information transmission and block the major pathways involved in cancer cell growth and division. Because ErbB family information transduction mechanism can be triggered by multiple homodimers and heterodimers, simultaneous inhibition of multiple ErbB family members (such as EGFR, HER2, ErbB3 and ErbB4) can effectively interrupt the downstream information transduction.
The action of sunitinib can irreversibly bind to the ErbB family receptor, interrupt the downstream signaling pathway, thereby preventing cancer cell growth and inducing apoptosis (programmed cell death). Therefore, compared with other targeted agents, characteristics of afatinib and ErbB receptors bind irreversibly to provide more lasting and selective, covalent and completely interrupted by the information transmission of cancer cells, leading to cancer treatment benefits unique, the growth of tumor cells have more potential to inhibit the broad categories of its curative effect also more note.
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