Oxaliplatin, also known as oxaliplatin, Eloxatin, part of the new derivatives of platinum, is a stereoisomer conjugate by generating alkylating effect on DNA, is formed between the chain and the chain crosslinking inhibition of DNA synthesis and replication. Is the second cisplatin, carboplatin after the third generation of new platinum-based anti-tumor compounds, mainly used in the clinical treatment after fluorouracil failure in patients with colorectal cancer metastasis, can be used alone or in combination with fluorouracil, and so far the only significant for colorectal cancer, the activity of platinum complex drugs.
Oxaliplatin is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX for the treatment of colorectal cancer. Oxaliplatin is marketed by Sanofi-Aventis under the trademark Eloxatin or by MedacGmbH under the trademark Oxaliplatin Medac. There are generic equivalents on the market now Oxaliplatin has been compared with other platinum compounds (Cisplatin, Carboplatin) in advanced cancers (gastric, ovarian).
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