Cisplatin (CAS No.:15663-27-1) is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.
This product is a heavy metal complex center at two price of platinum with two chlorine atoms and two ammoniamolecule, similar to the bifunctional alkylating agent, can inhibit the DNA replication process. The most sne DDP cells, high concentrations inhibit RNA and protein synthesis. The lack of effect of oxygen cells, into the human body can diffuse through the cell membrane charged. At present, the main site of DDP in DNA of the purine and pyrimidine bases. Effect: This product is a cell cycle non-specific drugs, has the cell toxicity, the process of DNA replication can inhibit cancer cells, and damage to the cell membrane structure, a broad-spectrum anticancer role.
