Cisplatin （CAS:15663-27-1） is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.
Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors.Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%. In addition, Cisplatin is used in Auger therapy.
Cisplatin is used together with other medications to treat bladder cancer, testicular cancer, or ovarian cancer.
Cisplatin can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before you receive cisplatin, tell your doctor about all other medications you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys. Call your doctor if you have little or no urinating, swelling or rapid weight gain, or shortness of breath.
Cisplatin can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches). Cisplatin can also affect your nervous system. Call your doctor if you have hearing problems, trouble with walking or daily activities, numbness, tingling, or cold feeling in your hands or feet.
Usage:
Cisplatin is administered intravenously as short-term infusion in physiological saline for treatment of solid malignacies.
Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) is a platinum-based chemotherapydrug used to treat various types of cancers, including sarcomas, somecarcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, andgerm cell tumors
Application:
It was the first member of a class of anti-cancer drugs which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA which ultimately triggers apoptosis (programmed cell death).
